CP 945
CP-945598 HCl
CAS: 686347-12-6
Molecular Formula: C25H26Cl3N7O
CP 945 - Names and Identifiers
CP 945 - Physico-chemical Properties
| Molecular Formula | C25H26Cl3N7O |
| Molar Mass | 546.87924 |
| Melting Point | 275-276℃ (decomposition) |
| Solubility | DMSO 1 mg/mL heat Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| Use | A selective and high affinity CB1 antagonist. |
| In vitro study | CP-945598 HCl inhibits the CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate central nervous system penetration. CP-945598 HCl acts on the human CB2 receptor with a low affinity, K I of 7.6 μm. |
| In vivo study | After CP-55940 treatment with synthetic CB1 receptor agonists, the CP-945598 of HCl reverses four cannabinoid agonist-mediated behaviors (spontaneous activity, hypothermia, analgesia, and general rigidity). CP-945598 HCl treated rodent models of acute food intake with loss of appetite and increased energy expenditure and fat oxidation. CP-945598 treatment of rats, severe stimulation of energy expenditure, and decreased the respiratory quotient, indicating metabolic conversion to increased fat oxidation. CP-945598 treated diet-induced obese mice at a dose of 10 mg/kg, CP-945598 promoted 9% weight loss in a 10-day weight loss study. |
CP 945 - Risk and Safety
| WGK Germany | 3 |
CP 945 - Introduction
Otenabant (CP-945598) HCl is an effective, selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, which is 10,000 times more selective than acting on human CB2 receptors.
Last Update：2022-10-16 17:41:46
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Spot supply
Product Name: CP-945598 HCl Visit Supplier Webpage Request for quotationCAS: 686347-12-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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